rs11586259 - RHOU - LINC02814
Magnitude 2.2 · 1 study on file
Reported associations
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Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449
ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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strict daily sun protection High
T allele increases basal cell carcinoma risk; UV exposure is primary modifiable risk factor for skin cancer
daily SPF 30+ sunscreen to exposed skin, protective clothing (hat, long sleeves), limit sun exposure 10am-4pm
Screening
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dermatological screening for skin cancer High
T allele at rs11586259 associated with increased basal cell carcinoma risk; regular screening enables early detection and improved outcomes
annual full-body skin examination by dermatologist; baseline exam if not recently done