rs11584032 - GIPC2 - RNFT1P2

Magnitude 2.0 · 1 study on file

Reported associations

• Investigating the shared genetic architecture between COVID-19 and obesity: a large-scale genome wide cross-trait analysis - Frontiers in endocrinology (2024) · Chen Y, Fan C, Liu J · PubMed 38352709

  ABSTRACT: Observational studies have reported high comorbidity between obesity and severe COVID-19. The aim of this study is to explore whether genetic factors are involved in the co-occurrence of the two traits. Based on the available genome-wide association studies (GWAS) summary statistics, we explored the genetic correlation and performed cross-trait meta-analysis (CPASSOC) and colocalization analysis (COLOC) to detect pleiotropic single nucleotide polymorphisms (SNPs). At the genetic level, we obtained genes detected by Functional mapping and annotation (FUMA) and the Multi-marker Analysis of GenoMic Annotation (MAGMA). Potential functional genes were further investigated by summary-data-based Mendelian randomization (SMR). Finally, the casualty was identiied using the latent causal v

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