rs115828022 - CAPZA3 - RPL7P6
Magnitude 4.5 · 1 study on file
Reported associations
-
Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids - Unknown journal (n.d.) · Unknown authors · PubMed 40537477
ABSTRACT: Serum lipid levels, which are influenced by both genetic and environmental factors, are key determinants of cardiometabolic health and are influenced by both genetic and environmental factors. Improving our understanding of their underlying biological mechanisms can have important public health and therapeutic implications. Although psychosocial factors, including depression, anxiety, and perceived social support, are associated with serum lipid levels, it is unknown if they modify the effect of genetic loci that influence lipids. We conducted a genome-wide gene-by-psychosocial factor interaction (G×Psy) study in up to 133,157 individuals to evaluate if G×Psy influences serum lipid levels. We conducted a two-stage meta-analysis of G×Psy using both a one-degree of freedom (1df)
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
-
LDL management considering genetic and social factors Moderate
This SNP shows a gene-by-environment interaction where LDL elevation is attenuated by good social support
Lifestyle
-
prioritize social connection and support network Moderate
LDL elevation associated with this SNP is modulated by social support; low social support amplifies genetic risk
Regular social engagement, maintain relationships, consider community activities
Screening
-
lipid panel for LDL and total cholesterol Moderate
This variant is associated with elevated LDL, particularly in context of low social support
Annual lipid panel, or more frequently if other cardiovascular risk factors present