Expressive

rs115825287 - GALNT18

Magnitude 2.8 · 2 studies on file

Reported associations

  • Novel functional insights into ischemic stroke biology provided by the first genome-wide association study of stroke in indigenous Africans - Unknown journal (n.d.) · Unknown authors · PubMed 38317187

    ABSTRACT: Background African ancestry populations have the highest burden of stroke worldwide, yet the genetic basis of stroke in these populations is obscure. The Stroke Investigative Research and Educational Network (SIREN) is a multicenter study involving 16 sites in West Africa. We conducted the first-ever genome-wide association study (GWAS) of stroke in indigenous Africans. Methods Cases were consecutively recruited consenting adults (aged > 18 years) with neuroimaging-confirmed ischemic stroke. Stroke-free controls were ascertained using a locally validated Questionnaire for Verifying Stroke-Free Status. DNA genotyping with the H3Africa array was performed, and following initial quality control, GWAS datasets were imputed into the NIH Trans-Omics for Precision Medicine (TOPMed) rele

  • A GWAS Meta-Analysis of Stroke in 22,000 individuals of African descent identifies novel associations with stroke - Unknown journal (n.d.) · Unknown authors · PubMed 32693751

    ABSTRACT: Background and Purpose Stroke is a complex disease with multiple genetic and environmental risk factors. African Americans endure a nearly two-fold greater risk of stroke and are 2-3 times more likely to die from stroke than European Americans. Methods The Consortium of Minority Population genome-wide Association Studies of Stroke (COMPASS) has conducted a genome-wide association meta-analysis of stroke in more than 22,000 individuals of African ancestry (3,734 cases, 18,317 controls) from 13 cohorts. Results In meta-analyses, we identified one SNP (rs55931441) near the HNF1A gene that reached genome-wide significance (P = 4.62×10−8) and an additional 29 variants with suggestive evidence of association (P < 1×10−6), representing 24 unique loci. For validation, a look-up a

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