rs115798498 - BZW1
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure - Unknown journal (n.d.) · Unknown authors · PubMed 29739929
ABSTRACT: The skin's tendency to sunburn rather than tan is a major risk factor for skin cancer. Here we report a large genome-wide association study of ease of skin tanning in 176,678 subjects of European ancestry. We identify significant association with tanning ability at 20 loci. We confirm previously identified associations at six of these loci, and report 14 novel loci, of which ten have never been associated with pigmentation-related phenotypes. Our results also suggest that variants at the AHR/AGR3 locus, previously associated with cutaneous malignant melanoma the underlying mechanism of which is poorly understood, might act on disease risk through modulation of tanning ability. The skin's tanning response to sun exposure shows great interindividual variability. Here, Visconti
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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broad-spectrum sunscreen SPF 30+ Moderate
UV protection reduces skin cancer development risk in individuals with genetic predisposition to non-melanoma skin cancer
apply daily to exposed skin, reapply every 2 hours during sun exposure
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excessive sun exposure Moderate
Cumulative ultraviolet radiation is the primary environmental driver of non-melanoma skin cancer; genetic predisposition increases vulnerability
limit direct sun exposure, seek shade between 10am-4pm, wear protective clothing
Screening
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dermatologic skin cancer screening Moderate
Genetic variant rs115798498 in BZW1 increases non-melanoma skin cancer risk; regular screening enables early detection and treatment
annual full-body skin exam by dermatologist