rs1157705 - OTOL1 - TOMM22P6

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide association study of antibody responses to Plasmodium falciparum candidate vaccine antigens. - Genes and immunity (2016) · Milet J, Sabbagh A, Migot-Nabias F, Luty AJ, Gaye O, Garcia A, Courtin D · PubMed 26741287

  We conducted a genome-wide association study (GWAS) of antibody responses directed to three Plasmodium falciparum vaccine candidate antigens (MSP1, MSP2 and GLURP) previously associated with different patterns of protection against malaria infection in Senegalese children. A total of 174 950 single-nucleotide polymorphisms (SNPs) were tested for association with immunoglobulin G1 (IgG1) responses directed to MSP1 and to GLURP and with IgG3 responses to MSP2 FC27 and to MSP2 3D7. We first performed a single-trait analysis with each antibody response and then a multiple-trait analysis in which we analyzed simultaneously the three immune responses associated with the control of clinical malaria episodes. Suggestive associations (P<1 × 10(-4)) were observed for 25 SNPs in MSP1 antibody resp

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