Expressive

rs11576687 - CTRC

Magnitude 2.2 · 1 study on file

Reported associations

  • A year of COVID-19 GWAS results from the GRASP portal reveals potential genetic risk factors - Unknown journal (n.d.) · Unknown authors · PubMed 35224516

    ABSTRACT: Host genetic variants influence the susceptibility and severity of several infectious diseases, and the discovery of genetic associations with coronavirus disease 2019 (COVID-19) phenotypes could help to develop new therapeutic strategies to decrease its burden. Between May 2020 and June 2021, we used COVID-19 data released periodically by UK Biobank and performed 65 genome-wide association studies in up to 18 releases of COVID-19 susceptibility (n = 18,481 cases in June 2021), hospitalization (n = 3,260), severe outcomes (n = 1,244), and deaths (n = 1,104), stratified by sex and ancestry. In coherence with previous studies, we observed two independent signals at the chr3p21.31 locus (rs73062389-A, odds ratio [OR], 1.21 (P = 4.26 × 10−15) and rs71325088-C, OR, 1.62 [P = 2.25

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Genetic risk stratification for COVID-19 severity Moderate

    T allele at rs11576687 associates with 1.3x increased COVID-19 mortality and severe disease risk.

    Share genotype information and discuss individual risk assessment and prevention personalization.

Lifestyle

  • Enhanced COVID-19 prevention if exposure anticipated Moderate

    T allele at rs11576687 is associated with increased COVID-19 severity and mortality (GWAS p=4e-6 and p=5e-6).

    When exposure likely, use N95 masks, improve ventilation, consider isolation; discuss specific measures with doctor.

Screening

  • COVID-19 vaccination and booster currency Moderate

    Genetic predisposition to severe COVID-19 increases value of maximal vaccination protection.

    Confirm up-to-date with current COVID-19 vaccines and boosters per current guidelines.