rs115765562 - UGT2B15 - UGT2B10

Magnitude 2.2 · 1 study on file

Reported associations

• The Contribution of Common Genetic Variation to Nicotine and Cotinine Glucuronidation in Multiple Ethnic/Racial Populations - Unknown journal (n.d.) · Unknown authors · PubMed 25293881

  ABSTRACT: Background The lung cancer risk of smokers varies by race/ethnicity even after adjustment for smoking. Evaluating the role of genetics in nicotine metabolism is likely important in understanding these differences, as disparities in risk may be related to differences in nicotine dose and metabolism. Methods We conducted a genome-wide association study in search of common genetic variants that predict nicotine and cotinine glucuronidation in a sample of 2,239 smokers (437 European Americans, 364 African Americans, 453 Latinos, 674 Japanese Americans and 311 Native Hawaiians) in the Multiethnic Cohort Study. Urinary concentration of nicotine and its metabolites were determined. Results Among 11,892,802 variants analyzed, 1,241 were strongly associated with cotinine glucuronidation,

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