rs11574358 - WRN

Magnitude 4.5 · 1 study on file

Reported associations

• Genetics of aging, health, and survival: dynamic regulation of human longevity related traits - Unknown journal (n.d.) · Unknown authors · PubMed 25918517

  ABSTRACT: Background: The roles of genetic factors in human longevity would be better understood if one can use more efficient methods in genetic analyses and investigate pleiotropic effects of genetic variants on aging and health related traits. Data and methods: We used EMMAX software with modified correction for population stratification to perform genome wide association studies (GWAS) of female lifespan from the original FHS cohort. The male data from the original FHS cohort and male and female data combined from the offspring FHS cohort were used to confirm findings. We evaluated pleiotropic effects of selected genetic variants as well as gene-smoking interactions on health and aging related traits. Then we reviewed current knowledge on functional properties of genes related to detec

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