Expressive

rs115726216 - CAMK2B

Magnitude 2.2 · 1 study on file

Reported associations

  • The power of genetic diversity in genome-wide association studies of lipids - Unknown journal (n.d.) · Unknown authors · PubMed 34887591

    ABSTRACT: Elevated blood lipid levels are heritable risk factors of cardiovascular disease with varying prevalence worldwide due to differing dietary patterns and medication use. Despite advances in prevention and treatment, particularly through the lowering of low-density lipoprotein cholesterol levels, heart disease remains the leading cause of death worldwide. Genome-wide association studies (GWAS) of blood lipid levels have led to important biological and clinical insights, as well as new drug targets, for cardiovascular disease. However, most previous GWAS have been conducted in European ancestry populations and may have missed genetic variants contributing to lipid level variation in other ancestry groups due to differences in allele frequencies, effect sizes, and linkage-disequilibr

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • lipid panel (LDL and total cholesterol) Moderate

    rs115726216 T allele is associated with elevated LDL cholesterol (effect=0.209) and total cholesterol (effect=0.200) in large population studies.

    lipid panel every 1-2 years; consider annual if baseline is elevated

Diet

  • cholesterol-lowering dietary pattern Moderate

    Elevated cholesterol from this variant may be partially modifiable through diet emphasizing unsaturated fats, whole grains, fiber, and plant-based foods.

    Mediterranean or DASH diet pattern as first-line approach for lipid management

Discuss with your doctor

  • cardiovascular risk assessment and lipid management strategy Moderate

    The T allele's association with elevated LDL and total cholesterol warrants discussion of cardiovascular risk factors and individualized management approach.

    discuss at routine visit; consider 10-year CVD risk assessment if age-appropriate