Expressive

rs11568822 - APOC1

Magnitude 2.2 · 2 studies on file

Reported associations

  • Identification of 16 novel Alzheimer's disease loci using multi‐ancestry meta‐analyses - Unknown journal (n.d.) · Unknown authors · PubMed 39998322

    ABSTRACT: Abstract INTRODUCTION Alzheimer's disease (AD) is the most prevalent form of dementia. While many AD‐associated genetic determinants have been identified, few studies have analyzed individuals of non‐European ancestry. METHODS We conducted a multi‐ancestry genome‐wide association study (GWAS) of clinically diagnosed AD and AD‐by‐proxy using whole genome sequencing data from the National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site (NIAGADS), National Institute of Mental Health, UK Biobank (UKB), and All of Us (AoU) consisting of 49,149 cases (12,074 clinically diagnosed and 37,075 AD‐by‐proxy) and 383,225 controls. Nearly half of NIAGADS and AoU participants were of non‐European ancestry. RESULTS For clinically diagnosed AD, we identified

  • A Genome-Wide Association Study of Metabolic Syndrome in the Taiwanese Population - Unknown journal (n.d.) · Unknown authors · PubMed 38201907

    ABSTRACT: The purpose of this study was to investigate genetic factors associated with metabolic syndrome (MetS) by conducting a large-scale genome-wide association study (GWAS) in Taiwan, addressing the limited data on Asian populations compared to Western populations. Using data from the Taiwan Biobank, comprehensive clinical and genetic information from 107,230 Taiwanese individuals was analyzed. Genotyping data from the TWB1.0 and TWB2.0 chips, including over 650,000 single nucleotide polymorphisms (SNPs), were utilized. Genotype imputation using the 1000 Genomes Project was performed, resulting in more than 9 million SNPs. MetS was defined based on a modified version of the Adult Treatment Panel III criteria. Among all participants (mean age: 50 years), 23% met the MetS definition. GW

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Screening

  • Cognitive function screening High

    rs11568822 associated with markedly elevated Alzheimer's disease risk; early assessment enables intervention

    Cognitive testing at baseline and annually starting at age 50

  • Metabolic syndrome screening Moderate

    APOC1 variant associated with metabolic syndrome risk; proactive monitoring detects metabolic dysfunction early

    Annual screening: fasting glucose, lipid panel, blood pressure, waist circumference