rs1156725 - SOX6
Magnitude 2.2 · 1 study on file
Reported associations
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The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals - Unknown journal (n.d.) · Unknown authors · PubMed 27618452
ABSTRACT: To dissect the genetic architecture of blood pressure and assess effects on target-organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure loci, of which 17 were novel and 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular tone across multiple tissues. The 66 index SNPs combined in a risk score showed comparable effects in 64,421 individuals of non-European descent. The 66-SNP blood pressure risk score was significantl
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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Sodium intake management Moderate
rs1156725 T allele carriers have elevated blood pressure risk; sodium reduction is primary dietary intervention
Maintain sodium intake below 2300 mg daily; target 1500-2000 mg if hypertensive
Exercise
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Aerobic exercise for blood pressure Moderate
Regular aerobic activity reduces blood pressure; especially important for rs1156725 carriers with genetic risk
150 minutes of moderate-intensity aerobic exercise per week
Screening
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Blood pressure monitoring Moderate
rs1156725 T allele is associated with higher systolic (0.447 mmHg) and diastolic (0.292 mmHg) blood pressure
Annual blood pressure checks; discuss more frequent monitoring if baseline is elevated