rs115656245 - OR8A1

Magnitude 2.2 · 1 study on file

Reported associations

• Crosstalk between Host Genome and Metabolome among People with HIV in South Africa - Unknown journal (n.d.) · Unknown authors · PubMed 35888748

  ABSTRACT: Genome-wide association studies (GWAS) of circulating metabolites have revealed the role of genetic regulation on the human metabolome. Most previous investigations focused on European ancestry, and few studies have been conducted among populations of African descent living in Africa, where the infectious disease burden is high (e.g., human immunodeficiency virus (HIV)). It is important to understand the genetic associations of the metabolome in diverse at-risk populations including people with HIV (PWH) living in Africa. After a thorough literature review, the reported significant gene-metabolite associations were tested among 490 PWH in South Africa. Linear regression was used to test associations between the candidate metabolites and genetic variants. GWAS of 154 plasma meta

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