rs11564714 - TH
Magnitude 2.2 · 1 study on file
Reported associations
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Diversity and longitudinal records: Genetic architecture of disease associations and polygenic risk in the Taiwanese Han population - Unknown journal (n.d.) · Unknown authors · PubMed 40465716
ABSTRACT: We addressed the underrepresentation of non-European populations in genome-wide association studies (GWASs) by building HiGenome, a large-scale genetic resource for the Taiwanese Han population. Using a custom genotyping array, we integrated deidentified electronic medical records (2003 to 2021) with genomic data to enable GWASs, phenome-wide association studies, and polygenic risk score (PRS) analysis. Among 413,000 participants, 323,397 passed ancestry and quality control filtering. GWASs covered 1085 traits, focusing on diseases prevalent in Taiwan such as type 2 diabetes, chronic kidney disease, gout, and alcoholic liver damage. PRSs were calculated for 238 traits, with the strongest associations observed in musculoskeletal disorders. Incorporating PRS into clinical practice
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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HbA1c and fasting glucose Moderate
Regular monitoring of glucose metabolism is indicated for carriers with increased genetic diabetes risk
Annual or biennial testing, more frequently if prediabetic
Discuss with your doctor
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Type 2 diabetes prevention strategies Moderate
Personalized discussion of prevention approaches based on increased genetic predisposition optimizes outcomes
Screening
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Type 2 diabetes risk screening Moderate
Carriers of this variant have significantly increased Type 2 diabetes risk
Consider screening beginning at age 30 or earlier if other risk factors present