Expressive

rs11564258 - MUC19

Magnitude 4.5 · 2 studies on file

Reported associations

  • Meta-Analysis Increases to 71 the Tally of Confirmed Crohn's Disease Susceptibility Loci - Unknown journal (n.d.) · Unknown authors · PubMed 21102463

    [INTRO] We undertook a meta-analysis of six Crohn's disease (CD) genome-wide association studies (GWAS) comprising 6,333 cases and 15,056 controls, and followed up the top association signals in 15,694 cases, 14,026 controls and 414 parent/offspring trios. Thirty new susceptibility loci meeting genome-wide significance (P-value <5×10−8) were identified. A series of in silico analyses highlighted particular genes within these loci and, together with manual curation, implicated functionally interesting candidate genes including SMAD3, ERAP2, IL10, IL2RA, TYK2, FUT2, DNMT3a, DENND1B, BACH2 and TAGAP. Combined with previously confirmed loci, the results described here identify a total of 71 distinct loci with genome-wide significant evidence for association with Crohn's disease. [INTRO

  • Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease - Unknown journal (n.d.) · Unknown authors · PubMed 23128233

    ABSTRACT: Crohn's disease (CD) and ulcerative colitis (UC), the two common forms of inflammatory bowel disease (IBD), affect over 2.5 million people of European ancestry with rising prevalence in other populations. Genome-wide association studies (GWAS) and subsequent meta-analyses of CD and UC as separate phenotypes implicated previously unsuspected mechanisms, such as autophagy, in pathogenesis and showed that some IBD loci are shared with other inflammatory diseases. Here we expand knowledge of relevant pathways by undertaking a meta-analysis of CD and UC genome-wide association scans, with validation of significant findings in more than 75,000 cases and controls. We identify 71 new associations, for a total of 163 IBD loci that meet genome-wide significance thresholds. Most loci cont

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