rs115636515 - PLD5 - RSL24D1P4

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide imputation identifies novel associations and localises signals in idiopathic inflammatory myopathies - Unknown journal (n.d.) · Unknown authors · PubMed 36580032

  ABSTRACT: Objectives: The idiopathic inflammatory myopathies (IIM) are heterogeneous diseases, thought to be initiated by immune activation in genetically predisposed individuals. In this study we imputed variants from the Immunochip array using a large reference panel to fine-map associations and identify novel associations in IIM. Methods: We analysed 2,565 Caucasian IIM samples collected through the Myositis Genetics Consortium (MYOGEN) and 10,260 ethnically-matched controls. We imputed 1,648,116 variants from the Immunochip array using the Haplotype Reference Consortium panel and conducted association analysis on IIM, and clinical and serological subgroups. Results: The human leukocyte antigen (HLA) locus was consistently the most significantly associated region. Four non-HLA regions r

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