rs11562922 - LINC01378 - LINC02264
Magnitude 2.2 · 1 study on file
Reported associations
-
Genetic diversity fuels gene discovery for tobacco and alcohol use - Unknown journal (n.d.) · Unknown authors · PubMed 36477530
ABSTRACT: Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease and injury. These substances are used across the globe, yet genome-wide association studies have focused largely on individuals of European ancestries. Here we leveraged global genetic diversity across 3.4 million individuals from four major clines of global ancestry (approximately 21% non-European) to power the discovery and fine-mapping of genomic loci associated with tobacco and alcohol use, to inform function of these loci via ancestry-aware transcriptome-wide association studies, and to evaluate the genetic architecture and predictive power of polygenic risk within and across populations. We found that increases in s
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
-
genetic predisposition to smoking initiation Moderate
Variant rs11562922 associated with smoking initiation risk enables proactive discussion of prevention and cessation strategies
Discuss genetic risk factors and individualized prevention approaches with healthcare provider
Lifestyle
-
smoking initiation Moderate
Risk allele G is associated with increased smoking initiation risk through altered reward processing in nucleus accumbens and prefrontal cortex
Implement smoking avoidance strategies; seek cessation support if currently smoking