rs115626545 - CCSER1
Magnitude 4.5 · 1 study on file
Reported associations
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Whole genome sequence analysis of apparent treatment resistant hypertension status in participants from the Trans-Omics for Precision Medicine program - Unknown journal (n.d.) · Unknown authors · PubMed 38162683
ABSTRACT: Introduction: Apparent treatment-resistant hypertension (aTRH) is characterized by the use of four or more antihypertensive (AHT) classes to achieve blood pressure (BP) control. In the current study, we conducted single-variant and gene-based analyses of aTRH among individuals from 12 Trans-Omics for Precision Medicine cohorts with whole-genome sequencing data. Methods: Cases were defined as individuals treated for hypertension (HTN) taking three different AHT classes, with average systolic BP ≥ 140 or diastolic BP ≥ 90 mmHg, or four or more medications regardless of BP (n = 1,705). A normotensive control group was defined as individuals with BP < 140/90 mmHg (n = 22,079), not on AHT medication. A second control group comprised individuals who were treatment responsive on o
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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CCSER1 variant and hypertension management strategy Moderate
Genetic predisposition to treatment-resistant hypertension may require adjusted clinical management approach
Inform healthcare provider of this genetic variant when discussing hypertension diagnosis or management
Screening
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blood pressure monitoring for hypertension risk Moderate
CCSER1 variant associated with treatment-resistant hypertension, necessitating proactive blood pressure assessment
Establish baseline blood pressure; monitor regularly and report persistent elevations to physician