rs115611612 - FBLN7
Magnitude 4.5 · 1 study on file
Reported associations
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Variants at the MHC Region Associate With Susceptibility to Clostridioides difficile Infection: A Genome-Wide Association Study Using Comprehensive Electronic Health Records - Unknown journal (n.d.) · Unknown authors · PubMed 33841421
ABSTRACT: Background Clostridioides difficile is a major cause of healthcare-associated and community-acquired diarrhea. Host genetic susceptibility to Clostridioides difficile infection has not been studied on a large-scale. Methods A total of 1,160 Clostridioides difficile infection cases and 15,304 controls were identified by applying the eMERGE Clostridioides difficile infection algorithm to electronic health record data. A genome-wide association study was performed using a linear mixed model, adjusted for significant covariates in the full dataset and the antibiotic subgroup. Colocalization and MetaXcan were performed to identify potential target genes in Clostridioides difficile infection - relevant tissue types. Results No significant genome-wide association was found in the meta-a
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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necessity and alternatives to antibiotics Moderate
rs115611612 A-allele carriers show 1.66-fold increased C. difficile infection risk when gut microbiota is disrupted by antibiotics.
When antibiotics are prescribed, discuss with your healthcare provider whether they are essential and if alternatives exist.
Screening
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C. difficile infection symptoms after antibiotic use Moderate
Genetically susceptible carriers have elevated risk for symptomatic C. difficile when bacterial balance is disrupted.
After starting antibiotics, monitor for watery diarrhea, abdominal cramping, fever within 1-10 days of exposure. Seek immediate care if symptoms develop.