Expressive

rs115599607 - ARHGEF38

Magnitude 2.2 · 2 studies on file

Reported associations

  • GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 - Unknown journal (n.d.) · Unknown authors · PubMed 37198478

    ABSTRACT: Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown to be highly efficient for discovery of genetic associations. Despite the advanced stage of illness at presentation, we have shown that host genetics in patients who are critically ill with COVID-19 can identify immunomodulatory therapies with strong beneficial effects in this group. Here we analyse 24,202 cases of COVID-19 with critical illness comprising a combination of microarray genotype and whole-genome sequencing data from cases of critical illness in the international GenOMICC (11,440 cases) study, combined with other studies recruiting hospitalized patients with a strong focus on severe and critical disease: ISARIC4C (676 cases) and the SCOURGE consortium

  • Novel risk loci for COVID-19 hospitalization among admixed American populations - Unknown journal (n.d.) · Unknown authors · PubMed 39361370

    ABSTRACT: The genetic basis of severe COVID-19 has been thoroughly studied, and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in the SCOURGE consortium, we conducted a genome-wide association study (GWAS) for COVID-19 hospitalization in admixed Americans, comprising a total of 4702 hospitalized cases recruited by SCOURGE and seven other participating studies in the COVID-19 Host Genetic Initiative. We identified four genome-wide significant associations, two of which constitute novel loci and were first discovered in Latin American populations (BAZ2B and DDIAS). A trans-ethnic meta-analysis revealed another novel

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • COVID-19 hospitalization risk Moderate

    ARHGEF38 variant alters gene expression and is associated with increased COVID-19 hospitalization risk

Screening

  • COVID-19 symptoms and severity signs Moderate

    Genetic variant affecting gene expression is associated with higher risk of severe COVID-19

    Monitor for fever, persistent cough, shortness of breath; seek evaluation if symptoms develop