Expressive

rs115576427 - SLCO6A1

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide association study and trans-ethnic meta-analysis identify novel susceptibility loci for type 2 diabetes mellitus - Unknown journal (n.d.) · Unknown authors · PubMed 38685053

    ABSTRACT: Background The genetic basis of type 2 diabetes (T2D) is under-investigated in the Middle East, despite the rapidly growing disease prevalence. We aimed to define the genetic determinants of T2D in Qatar. Methods Using whole genome sequencing of 11,436 participants (2765 T2D cases and 8671 controls) from the population-based Qatar Biobank (QBB), we conducted a genome-wide association study (GWAS) of T2D with and without body mass index (BMI) adjustment. Results We replicated 93 known T2D-associated loci in a BMI-unadjusted model, while 96 known loci were replicated in a BMI-adjusted model. The effect sizes and allele frequencies of replicated SNPs in the Qatari population generally concurred with those from European populations. We identified a locus specific to our cohort locate

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Refined carbohydrates and added sugars Moderate

    High glycemic load impairs glucose control; particularly critical to minimize with genetic T2D predisposition

    Limit refined grains, sugary drinks, and desserts; prioritize whole grains and vegetables

Discuss with your doctor

  • Type 2 diabetes risk and prevention strategies Moderate

    G allele at rs115576427 increases T2D risk, warranting discussion of individualized prevention approaches

Exercise

  • Regular physical activity Moderate

    Exercise improves insulin sensitivity and glucose control in individuals with genetic T2D predisposition

    150 minutes moderate aerobic activity plus 2 sessions resistance training per week

Screening

  • Type 2 diabetes screening Moderate

    G allele at rs115576427 is significantly associated with increased Type 2 diabetes risk in large GWAS

    Annual HbA1c and fasting glucose testing starting at age 30