rs115567901 - DYNC1I2 - SLC25A12

Magnitude 4.5 · 1 study on file

Reported associations

• Differential Genetic Architecture of Insulin Resistance (HOMA-IR) Based on Obesity Status: Evidence from a Large-Scale GWAS of Koreans - Unknown journal (n.d.) · Unknown authors · PubMed 40699860

  ABSTRACT: Insulin resistance (IR) is a key mechanism underlying type 2 diabetes mellitus and is closely associated with obesity. Although numerous genome-wide association studies (GWASs) have identified variants that influence IR-related traits, it remains unclear whether the genetic architecture of IR differs according to obesity status. We conducted a stratified GWAS of the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) in 8906 Korean individuals from the Korean Genome and Epidemiology Study. Participants were categorized into a normal-weight group (Body Mass Index (BMI) ≤ 23 kg/m2) and an overweight or obese group (BMI > 23 kg/m2), and the GWAS was performed separately within each group. No significant genome-wide variants were identified in the normal-weight group; howe

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