Expressive

rs115552537 - BARHL2 - LINC02609

Magnitude 2.2 · 2 studies on file

Reported associations

  • Physical and neuro-behavioural determinants of reproductive onset and success - Unknown journal (n.d.) · Unknown authors · PubMed 27089180

    ABSTRACT: The ages of puberty, first sexual intercourse and first birth signify the onset of reproductive ability, behaviour and success, respectively. These sequenced events have behavioural, physiological and health significance, and may also influence overall reproductive fitness. In a genome-wide association study of 125,667 white men and women aged 40-69 in the UK Biobank Study, we identify 38 sequence variants with association P-values <5×10-8 with age at first sexual intercourse. Findings were taken forward in up to 241,910 men and women from deCODE Iceland and 20,187 from Women's Genome Health Study. Several of these loci also exhibit strong associations with behavioural traits (rs4856591 in CADM2 and risk taking propensity: P=4.3×10-10; rs73195303 in MSRA and irritable tempera

  • Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures - Unknown journal (n.d.) · Unknown authors · PubMed 40436827

    ABSTRACT: Genome-wide association studies (GWAS) have predominantly focused on European ancestry populations, limiting biological discoveries across diverse populations. Here we report GWAS findings from 153,950 individuals across 36 quantitative traits in the Korean Cancer Prevention Study-II (KCPS2) Biobank. We discovered 301 previously unreported genetic loci in KCPS2, including an association between thyroid-stimulating hormone and CD36. Meta-analysis with the Korean Genome and Epidemiology Study, Biobank Japan, Taiwan Biobank, and UK Biobank identified 4588 loci that were not significant in any contributing GWAS. We describe differences in genetic architectures across these East Asian and European samples. We also highlight East Asian specific associations, including a known pleiotrop

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.