rs11554586 - BIN1

Magnitude 2.2 · 1 study on file

Reported associations

• Whole exome sequencing analyses identified novel genes for Alzheimer's disease and related dementia - Unknown journal (n.d.) · Unknown authors · PubMed 39129223

  ABSTRACT: Abstract INTRODUCTION The heritability of Alzheimer's disease (AD) is estimated to be 58%-79%. However, known genes can only partially explain the heritability. METHODS Here, we conducted gene‐based exome‐wide association study (ExWAS) of rare variants and single‐variant ExWAS of common variants, utilizing data of 54,569 clinically diagnosed/proxy AD and related dementia (ADRD) and 295,421 controls from the UK Biobank. RESULTS Gene‐based ExWAS identified 11 genes predicting a higher ADRD risk, including five novel ones, namely FRMD8, DDX1, DNMT3L, MORC1, and TGM2, along with six previously reported ones, SORL1, GRN, PSEN1, ABCA7, GBA, and ADAM10. Single‐variant ExWAS identified two ADRD‐associated novel genes, SLCO1C1 and NDNF. The identified genes were predominantl

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