rs11554266 - GNAS

Magnitude 2.0 · 1 study on file

Reported associations

• Identification of CDC42BPG as a novel susceptibility locus for hyperuricemia in a Japanese population - Unknown journal (n.d.) · Unknown authors · PubMed 29124443

  ABSTRACT: Chronic kidney disease and hyperuricemia are serious global health problems. Recent genome-wide association studies have identified various genetic variants related to these disorders. However, most studies have been conducted in a cross-sectional manner. To identify novel susceptibility loci for chronic kidney disease or hyperuricemia, we performed longitudinal exome-wide association studies (EWASs), using ~ 244,000 genetic variants and clinical data of Japanese individuals who had undergone annual health checkups for several years. After establishing quality controls, the association of renal function-related traits in 5648 subjects (excluding patients with dialysis and population outliers) with 24,579 single nucleotide variants (SNVs) for three genetic models (P < 3.39

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