Expressive

rs11554257 - TNFSF15 - DELEC1

Magnitude 2.2 · 2 studies on file

Reported associations

  • Genetic Predictors of Medically Refractory Ulcerative Colitis - Unknown journal (n.d.) · Unknown authors · PubMed 20848476

    ABSTRACT: Background Acute severe ulcerative colitis (UC) remains a significant clinical challenge and the ability to predict, at an early stage, those individuals at risk of colectomy for medically refractory UC (MR-UC) would be a major clinical advance. The aim of this study was to use a genome-wide association study (GWAS) in a well-characterized cohort of UC patients to identify genetic variation that contributes to MR-UC. Methods A GWAS comparing 324 MR-UC patients with 537 Non-MR-UC patients was analyzed using logistic regression and Cox proportional hazards methods. In addition, the MR-UC patients were compared with 2601 healthy controls. Results MR-UC was associated with more extensive disease (p= 2.7×10−6) and a positive family history of UC (p= 0.004). A risk score based on th

  • Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations - Unknown journal (n.d.) · Unknown authors · PubMed 26192919

    ABSTRACT: Ulcerative colitis and Crohn's disease are the two main forms of inflammatory bowel disease (IBD). Here, we report the first trans-ethnic association study of IBD, with genome-wide or Immunochip genotype data from an extended cohort of 86,640 European individuals and Immunochip data from 9,846 individuals of East-Asian, Indian or Iranian descent. We implicate 38 loci in IBD risk for the first time. For the majority of IBD risk loci, the direction and magnitude of effect is consistent in European and non-European cohorts. Nevertheless, we observe genetic heterogeneity between divergent populations at several established risk loci driven by a combination of differences in allele frequencies (NOD2), effect sizes (TNFSF15, ATG16L1) or a combination of both (IL23R, IRGM). Our result

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Discuss TNFSF15 rs11554257 genotype and ulcerative colitis genetic risk Moderate

    G allele confers 1.8-fold increased risk for severe ulcerative colitis through TNFSF15-driven T-cell-mediated intestinal inflammation

    Consult gastroenterologist to establish baseline screening and surveillance strategy for early disease detection

Screening

  • Monitor for ulcerative colitis symptoms Moderate

    rs11554257 G allele is a genome-wide significant risk factor for both ulcerative colitis susceptibility and severe disease requiring colectomy

    Report bloody stools, persistent diarrhea, abdominal pain, urgency, or unexplained weight loss to healthcare provider