rs1155422 - MTND1P22 - GUCY1A1
Magnitude 2.2 · 1 study on file
Reported associations
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Trans-ethnic association study of blood pressure determinants in over 750,000 individuals - Unknown journal (n.d.) · Unknown authors · PubMed 30578418
ABSTRACT: In this trans-ethnic multi-omic study we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenome, and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in GWASs of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our transcriptome-wide association study detected 4,043 blood pressure associations with genetically-predicted gene expression of 840 genes in 45 tissues, and murine renal single-cell RNA sequencing identified upregulated blood pressure genes in kidney tubule cells. Editorial summary: Analysis of blood pressure data from
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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pulse pressure assessment Moderate
T allele increases pulse pressure via GUCY1A1-mediated vascular smooth muscle stiffness
include pulse pressure measurement in annual cardiovascular checkup