rs115542129 - NEGR1
Magnitude 2.2 · 1 study on file
Reported associations
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Sex‐specific genetic architecture of late‐life memory performance - Unknown journal (n.d.) · Unknown authors · PubMed 37984853
ABSTRACT: Abstract BACKGROUND Women demonstrate a memory advantage when cognitively healthy yet lose this advantage to men in Alzheimer's disease. However, the genetic underpinnings of this sex difference in memory performance remain unclear. METHODS We conducted the largest sex‐aware genetic study on late‐life memory to date (N males = 11,942; N females = 15,641). Leveraging harmonized memory composite scores from four cohorts of cognitive aging and AD, we performed sex‐stratified and sex‐interaction genome‐wide association studies in 24,216 non‐Hispanic White and 3367 non‐Hispanic Black participants. RESULTS We identified three sex‐specific loci (rs67099044-CBLN2, rs719070-SCHIP1/IQCJ‐SCHIP), including an X‐chromosome locus (rs5935633-EGL6/TCEANC/OFD1), that
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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Mediterranean-style diet pattern Moderate
Antioxidant and omega-3-rich diet supports cognitive health; SNP associated with memory decline warrants dietary optimization.
Emphasize vegetables, fruits, whole grains, legumes, fish, olive oil
Discuss with your doctor
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Memory decline risk and prevention strategies Moderate
SNP associated with memory decline; proactive discussion enables personalized prevention planning.
Discuss cognitive function baseline, family history, and prevention strategies
Exercise
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Regular aerobic exercise Moderate
Physical activity supports neuroplasticity and cognitive function; may mitigate genetic susceptibility to decline.
150 minutes moderate-intensity aerobic exercise per week
Lifestyle
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Optimize sleep duration and consistency Moderate
Sleep consolidates memory; SNP associated with memory decline warrants attention to modifiable factors.
Target 7-9 hours nightly with consistent sleep and wake times
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Regular cognitive engagement and mental stimulation Moderate
SNP associated with memory decline; cognitive engagement supports memory preservation across lifespan.
Daily mentally stimulating activities (reading, puzzles, learning) for 30 minutes
Screening
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Memory function assessment Moderate
This SNP is associated with memory decline; periodic cognitive assessment enables early detection.
Annual cognitive screening starting at age 50