rs115539978 - LINC02335 - HNF4GP1

Magnitude 2.8 · 1 study on file

Reported associations

• International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci - Unknown journal (n.d.) · Unknown authors · PubMed 31594949

  ABSTRACT: The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls we conduct a genome-wide association study of PTSD. We demonstrate SNP-based heritability estimates of 5-20%, varying by sex. Three genome-wide significant loci are identified, 2 in European and 1 in African-ancestry analyses. Analyses stratified by sex implicate 3 additional loci in men. Along with other novel genes and non-coding RNAs, a Parkinson's disease gene involved in dopamine regulation, PARK2, is associated with PTSD. Finally, we demonstrate that polygenic risk for PTSD is significantly predictive of re-experiencing symptoms in the Million Veteran Program d

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