Expressive

rs115528845 - PLEKHH2

Magnitude 2.2 · 2 studies on file

Reported associations

  • Bidirectional relationship between type 2 diabetes mellitus and coronary artery disease: Prospective cohort study and genetic analyses - Unknown journal (n.d.) · Unknown authors · PubMed 38062574

    ABSTRACT: Abstract Background: While type 2 diabetes mellitus (T2DM) is considered a putative causal risk factor for coronary artery disease (CAD), the intrinsic link underlying T2DM and CAD is not fully understood. We aimed to highlight the importance of integrated care targeting both diseases by investigating the phenotypic and genetic relationships between T2DM and CAD. Methods: We evaluated phenotypic associations using data from the United Kingdom Biobank (N = 472,050). We investigated genetic relationships by leveraging genomic data conducted in European ancestry for T2DM, with and without adjustment for body mass index (BMI) (T2DM: Ncase/Ncontrol = 74,124/824,006; T2DM adjusted for BMI [T2DMadjBMI]: Ncase/Ncontrol = 50,409/523,897) and for CAD (Ncase/Ncontrol = 181,522/984,168). We

  • Genetics of 35 blood and urine biomarkers in the UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 33462484

    ABSTRACT: Clinical laboratory tests are a critical component of the continuum of care. We evaluate the genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n=363,228 individuals). We identify 1,857 loci associated with at least one trait, containing 3,374 fine-mapped associations, and additional sets of large-effect (> 0.1 sd) protein-altering, HLA, and copy-number variant associations. Through Mendelian Randomization analysis, we discover 51 causal relationships, including previously known agonistic effects of urate on gout and cystatin C on stroke. Finally, we develop polygenic risk scores for each biomarker and built 'multi-PRS' models for diseases using 35 PRSs simultaneously, which improved chronic kidney disease, type 2 diabetes, gout, and alcoholic cirr

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • Fasting glucose and HbA1c testing Moderate

    Variant associated with elevated HbA1c levels and T2DM risk, indicating glucose dysregulation independent of BMI

    Annual testing if not diagnosed with diabetes, more frequent if prediabetic

Diet

  • Lower refined carbohydrate intake Moderate

    T2DM and HbA1c associations indicate metabolic benefit from improved dietary carbohydrate quality

    Emphasize whole grains, limit refined carbs and sugary beverages, maintain consistent meal timing

Discuss with your doctor

  • Personalized diabetes risk reduction strategy Moderate

    Large-scale GWAS shows increased T2DM genetic risk independent of BMI, warranting targeted clinical assessment

Exercise

  • Regular aerobic and resistance training Moderate

    T2DM GWAS association suggests significant metabolic benefit from consistent physical activity

    Target 150 minutes weekly moderate-intensity aerobic activity or equivalent strength training