Expressive

rs115516428 - RHBDD1

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide association study of susceptibility to hospitalised respiratory infections - Unknown journal (n.d.) · Unknown authors · PubMed 39220670

    ABSTRACT: Background: Globally, respiratory infections contribute to significant morbidity and mortality. However, genetic determinants of respiratory infections are understudied and remain poorly understood. Methods: We conducted a genome-wide association study in 19,459 hospitalised respiratory infection cases and 101,438 controls from UK Biobank (Stage 1). We followed-up well-imputed top signals from our Stage 1 analysis in 50,912 respiratory infection cases and 150,442 controls from 11 cohorts (Stage 2). We aggregated effect estimates across studies using inverse variance-weighted meta-analyses. Additionally, we investigated the function of the top signals in order to gain understanding of the underlying biological mechanisms. Results: From our Stage 1 analysis, we report 56 signals at

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • preventive strategies for respiratory infections Moderate

    Genetic predisposition to severe respiratory infections warrants clinical discussion of evidence-based preventive measures including vaccination strategies.

Exercise

  • aerobic exercise for respiratory health Moderate

    Regular aerobic exercise strengthens respiratory function and immune response, reducing infection susceptibility in genetically predisposed individuals.

    150 minutes moderate-intensity aerobic exercise per week

Lifestyle

  • cigarette smoke and air pollution exposure Moderate

    Environmental respiratory irritants exacerbate infection risk in genetically predisposed individuals with increased susceptibility to severe respiratory infections.

    Avoid secondhand smoke; monitor air quality; limit outdoor activity on poor air quality days

Screening

  • baseline respiratory health assessment Moderate

    Increased genetic risk for hospitalised respiratory infections warrants baseline assessment to identify modifiable risk factors and establish health reference.

    Schedule spirometry or respiratory assessment with healthcare provider