rs115506418 - LINC01735 - LINC02769
Magnitude 2.2 · 1 study on file
Reported associations
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DSP variants may be associated with longitudinal change in quantitative emphysema - Unknown journal (n.d.) · Unknown authors · PubMed 31324189
ABSTRACT: Background Emphysema, characterized by lung destruction, is a key component of Chronic Obstructive Pulmonary Disease (COPD) and is associated with increased morbidity and mortality. Genome-wide association studies (GWAS) have identified multiple genetic factors associated with cross-sectional measures of quantitative emphysema, but the genetic determinants of longitudinal change in quantitative measures of emphysema remain largely unknown. Our study aims to identify genetic variants associated with longitudinal change in quantitative emphysema measured by computed tomography (CT) imaging. Methods We included current and ex-smokers from two longitudinal cohorts: COPDGene, a study of Non-Hispanic Whites (NHW) and African Americans (AA), and the Evaluation of COPD Longitudinally to
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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genetic risk for accelerated emphysema Moderate
Variant associated with faster annual emphysema progression in smokers
Lifestyle
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smoking and secondhand smoke exposure Moderate
Variant carriers show significantly faster emphysema progression when exposed to tobacco smoke
Screening
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pulmonary function testing Moderate
Variant associated with accelerated emphysema progression measured by percent low attenuation area
Baseline PFT and annual follow-up in smokers; discuss screening timeline with physician