rs115503527 - HLA-DQA1
Magnitude 2.2 · 1 study on file
Reported associations
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Genetic insight into the relationship between inflammatory bowel disease and Clostridioides difficile infection - Unknown journal (n.d.) · Unknown authors · PubMed 39436105
ABSTRACT: ABSTRACT Patients with inflammatory bowel disease (IBD) are at increased risk of Clostridioides difficile infection (CDI). Herein, we aimed to determine if genetic risk contributes to this observed association. We carried out a genome-wide association study (GWAS) analysis in the Michigan Genomics Initiative and the United Kingdom Biobank for CDI based on ICD codes and meta-analyzed these results with similar publicly accessible GWAS summary statistics from Finngen. Conditional and joint multi-SNP analyses were used to identify independent associations. Imputation of the human leukocyte antigen (HLA) region with fine mapping was used to try to identify causal HLA allele groups. Two-sample bidirectional Mendelian randomization (MR) was implemented to determine causal relationships
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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antibiotic stewardship for C. difficile risk Moderate
The A allele at rs115503527 is associated with increased C. difficile infection susceptibility; minimizing unnecessary antibiotic exposure reduces personal infection risk.
discuss when antibiotics are medically necessary and explore alternatives when clinically appropriate
Screening
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C. difficile infection symptoms during/after antibiotics Moderate
Increased genetic susceptibility elevates risk upon C. difficile exposure; early symptom recognition enables prompt diagnosis and treatment.
watch for severe diarrhea, abdominal pain, or fever during/after antibiotic use and seek medical attention if symptoms develop