Expressive

rs11550299 - DPP3

Magnitude 2.2 · 2 studies on file

Reported associations

  • Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation - Unknown journal (n.d.) · Unknown authors · PubMed 35213538

    ABSTRACT: Large-scale molecular profiling and genotyping provide a unique opportunity to systematically compare the genetically predicted effects of therapeutic targets on the human metabolome. We firstly constructed genetic risk scores for 8 drug targets on the basis that they primarily modify low-density lipoprotein (LDL) cholesterol (HMGCR, PCKS9, and NPC1L1), high-density lipoprotein (HDL) cholesterol (CETP), or triglycerides (APOC3, ANGPTL3, ANGPTL4, and LPL). Conducting mendelian randomisation (MR) provided strong evidence of an effect of drug-based genetic scores on coronary artery disease (CAD) risk with the exception of ANGPTL3. We then systematically estimated the effects of each score on 249 metabolic traits derived using blood samples from an unprecedented sample size of up to

  • Decreased Circulating Very Small Low-Density Lipoprotein is Likely Causal for Age-Related Macular Degeneration - Unknown journal (n.d.) · Unknown authors · PubMed 39091897

    ABSTRACT: Objective Abnormal changes in metabolite levels in serum or plasma have been highlighted in several studies in age-related macular degeneration (AMD), the leading cause of irreversible vision loss. Specific changes in lipid profiles are associated with an increased risk of AMD. Metabolites could thus be used to investigate AMD disease mechanisms or incorporated into AMD risk prediction models. However, whether particular metabolites causally affect the disease has yet to be established. Design A 3-tiered analysis of blood metabolites in the United Kingdom (UK) Biobank cohort to identify metabolites that differ in AMD patients with evidence for a putatively causal role in AMD. Participants A total of 72 376 donors from the UK Biobank cohort including participants with AMD (N = 

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • Triglycerides and VLDL cholesterol levels Moderate

    rs11550299 is associated with altered triglyceride-to-total-lipids ratio in large VLDL particles indicating modified lipid metabolism

    Annual lipid panel with triglyceride and VLDL measurement

Diet

  • Limit refined carbohydrates and added sugars Moderate

    Refined carbohydrates elevate triglycerides, which is especially relevant given SNP association with VLDL triglyceride metabolism

    Replace refined grains and sugary foods with whole grains and complex carbohydrates

Discuss with your doctor

  • Cardiovascular risk stratification and lipid management Moderate

    VLDL lipid associations suggest potential cardiovascular risk warranting professional evaluation for personalized prevention strategy

    Schedule review of lipid results and cardiovascular risk assessment with healthcare provider

Exercise

  • Regular aerobic exercise for triglyceride reduction Moderate

    Aerobic exercise reduces triglycerides and improves VLDL metabolism, potentially mitigating genetic predisposition to elevated ratios

    150 minutes per week of moderate-intensity aerobic activity