rs115487787 - NRXN1

Magnitude 2.2 · 1 study on file

Reported associations

• Clinical and Genome-Wide Analysis of Serum Platinum Levels after Cisplatin-Based Chemotherapy - Unknown journal (n.d.) · Unknown authors · PubMed 31296530

  ABSTRACT: Purpose: Serum platinum is measurable for years after completion of cisplatin-based chemotherapy (CBC). We report the largest investigation of serum platinum levels to date of 1,010 testicular cancer survivors (TCS) assessed 1-35 years after CBC and evaluate genetic contributions to these levels. Experimental Design: Eligible TCS given 300 or 400 (±15) mg/m2 cisplatin underwent extensive audiometric testing, clinical examination, completed questionnaires and had crude serum platinum levels measured. Associations between serum platinum and various risk factors and toxicities were assessed after fitting a bi-exponential model adjusted for follow-up time and cumulative cisplatin dose. A genome-wide association study (GWAS) was performed using the serum platinum residuals of the dos

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