rs115481520 - ERBB4
Magnitude 2.8 · 1 study on file
Reported associations
-
Genetic association studies of alterations in protein function expose recessive effects on cancer predisposition - Unknown journal (n.d.) · Unknown authors · PubMed 34290314
ABSTRACT: The characterization of germline genetic variation affecting cancer risk, known as cancer predisposition, is fundamental to preventive and personalized medicine. Studies of genetic cancer predisposition typically identify significant genomic regions based on family-based cohorts or genome-wide association studies (GWAS). However, the results of such studies rarely provide biological insight or functional interpretation. In this study, we conducted a comprehensive analysis of cancer predisposition in the UK Biobank cohort using a new gene-based method for detecting protein-coding genes that are functionally interpretable. Specifically, we conducted proteome-wide association studies (PWAS) to identify genetic associations mediated by alterations to protein function. With PWAS, we i
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
-
dietary fiber intake Moderate
fiber associated with reduced colorectal cancer risk through improved gut health and reduced carcinogen exposure
aim for 25-35g daily from whole grains, legumes, vegetables, and fruits
Exercise
-
regular physical activity Moderate
physical activity associated with reduced colorectal cancer risk through improved gut motility and reduced insulin resistance
aim for 150 minutes moderate-intensity aerobic activity weekly plus strength training 2x weekly
Screening
-
early colorectal cancer screening Moderate
ERBB4 rs115481520 associated with 36.9% increased colorectal cancer risk in large GWAS cohort
discuss with gastroenterologist about earlier colonoscopy (age 40-45) or increased frequency (every 5 vs 10 years)