rs115474994 - UBTFL3 - GPAT2P1

Magnitude 2.0 · 1 study on file

Reported associations

• A genome-wide search for pleiotropy in more than 100,000 harmonized longitudinal cognitive domain scores - Unknown journal (n.d.) · Unknown authors · PubMed 37349795

  ABSTRACT: Background More than 75 common variant loci account for only a portion of the heritability for Alzheimer's disease (AD). A more complete understanding of the genetic basis of AD can be deduced by exploring associations with AD-related endophenotypes. Methods We conducted genome-wide scans for cognitive domain performance using harmonized and co-calibrated scores derived by confirmatory factor analyses for executive function, language, and memory. We analyzed 103,796 longitudinal observations from 23,066 members of community-based (FHS, ACT, and ROSMAP) and clinic-based (ADRCs and ADNI) cohorts using generalized linear mixed models including terms for SNP, age, SNP × age interaction, sex, education, and five ancestry principal components. Significance was determined based o

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