Expressive

rs115468973 - HLA-DRB6 - HLA-DRB1

Magnitude 2.8 · 1 study on file

Reported associations

  • Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct. - American journal of human genetics (2020) · Ferreira MAR, Mathur R, Vonk JM, Szwajda A, Brumpton B, Granell R, Brew BK, Ullemar V, Lu Y, Jiang Y, Magnusson PKE, Karlsson R, Hinds DA, Paternoster L, Koppelman GH, Almqvist C · PubMed 30929738

    The extent to which genetic risk factors are shared between childhood-onset (COA) and adult-onset (AOA) asthma has not been estimated. On the basis of data from the UK Biobank study (n = 447,628), we found that the variance in disease liability explained by common variants is higher for COA (onset at ages between 0 and 19 years; h = 25.6%) than for AOA (onset at ages between 20 and 60 years; h = 10.6%). The genetic correlation (r ) between COA and AOA was 0.67. Variation in age of onset among COA-affected individuals had a low heritability (h = 5%), which we confirmed in independent studies and also among AOA-affected individuals. To identify subtype-specific genetic associations, we performed a genome-wide association study (GWAS) in the UK Biobank for COA (13,962 affected individuals) a

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Genetic asthma predisposition risk Moderate

    GWAS evidence demonstrates T allele at rs115468973 confers increased asthma susceptibility independent of other factors

Lifestyle

  • Minimize exposure to asthma triggers Moderate

    HLA genetic predisposition increases airway reactivity to environmental irritants; avoiding triggers reduces cumulative disease risk

    Limit smoke, air pollution, and allergen exposure where feasible

Screening

  • Baseline spirometry and asthma screening Moderate

    HLA-DRB1 variants regulate immune responses to inhaled antigens; T allele carriers show 26.7% increased asthma odds

    Baseline spirometry test; periodic symptom assessment with healthcare provider