Expressive

rs115463537 - Y_RNA - LINC01896

Magnitude 4.5 · 2 studies on file

Reported associations

  • Genome-Wide Association Study of Breast Density among Women of African Ancestry - Unknown journal (n.d.) · Unknown authors · PubMed 37345113

    ABSTRACT: Simple Summary In the US, Black women are disproportionately affected by higher breast cancer mortality rates and later-stage tumor diagnoses compared with White women. Breast density, the ratio of dense fibroglandular breast tissue to overall breast tissue area, has previously been identified as an important breast cancer risk factor. Most current genome-wide association studies for breast density have been performed in participants of European ancestry, which have yielded important insights into genetic etiology of breast density. However, little is known about the influence of common genetic variants on breast density in African ancestry populations. Our study aimed to determine genetic factors associated with breast density in African ancestry populations using a Genome-Wide

  • Multi-ancestry genome-wide association study of 4069 children with glioma identifies 9p21.3 risk locus - Unknown journal (n.d.) · Unknown authors · PubMed 36810956

    ABSTRACT: Abstract Background Although recent sequencing studies have revealed that 10% of childhood gliomas are caused by rare germline mutations, the role of common variants is undetermined and no genome-wide significant risk loci for pediatric central nervous system tumors have been identified to date. Methods Meta-analysis of 3 population-based genome-wide association studies comprising 4069 children with glioma and 8778 controls of multiple genetic ancestries. Replication was performed in a separate case-control cohort. Quantitative trait loci analyses and a transcriptome-wide association study were conducted to assess possible links with brain tissue expression across 18 628 genes. Results Common variants in CDKN2B-AS1 at 9p21.3 were significantly associated with astrocytoma, the m

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