rs115460205 - FSTL5

Magnitude 2.0 · 1 study on file

Reported associations

• Ancestry-specific and sex-specific risk alleles identified in a genome-wide gene-by- alcohol dependence interaction study of risky sexual behaviors - American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics (2018) · Polimanti R, Zhao H, Farrer LA, Kranzler HR, Gelernter J · PubMed 28990359

  ABSTRACT: We previously mapped loci for the genome-wide association studies (GWAS) and genome-wide gene-by-alcohol dependence interaction (GW-GxAD) analyses of risky sexual behaviors (RSB). This study extends those findings by analyzing the ancestry- and sex-specific AD-stratified effects on RSB. We examined the concordance of findings for the AD-stratified GWAS and the GW-GxAD analysis of RSB, with concordance defined as genome-wide significance in one analysis and at least nominal significance in the second analysis. 2,173 African-American (AA) and 1,751 European-American (EA) subjects were investigated. Information regarding RSB (lifetime experiences of unprotected sex and multiple sexual partners) and DSM-IV diagnosis of lifetime AD were derived from the Semi-Structured Assessment for

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