rs115449435 - EGFEM1P
Magnitude 4.5 · 1 study on file
Reported associations
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Genome-wide association study of paliperidone efficacy - Unknown journal (n.d.) · Unknown authors · PubMed 27846195
ABSTRACT: Supplemental Digital Content is available in the text. Objective Clinical response to the atypical antipsychotic paliperidone is known to vary among schizophrenic patients. We carried out a genome-wide association study to identify common genetic variants predictive of paliperidone efficacy. Methods We leveraged a collection of 1390 samples from individuals of European ancestry enrolled in 12 clinical studies investigating the efficacy of the extended-release tablet paliperidone ER (n1=490) and the once-monthly injection paliperidone palmitate (n2=550 and n3=350). We carried out a genome-wide association study using a general linear model (GLM) analysis on three separate cohorts, followed by meta-analysis and using a mixed linear model analysis on all samples. The variations in r
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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paliperidone response with psychiatrist Moderate
rs115449435 T allele associated with improved paliperidone response in schizophrenia (effect size 6.148, p=7e-6)
If on or considering paliperidone therapy, share genotype with psychiatrist for treatment optimization