rs115447387 - ZYG11B
Magnitude 2.2 · 1 study on file
Reported associations
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A Developmentally-Informative Genome-wide Association Study of Alcohol Use Frequency. - Behavior genetics (2024) · Thomas NS, Gillespie NA, Chan G, Edenberg HJ, Kamarajan C, Kuo SI, Miller AP, Nurnberger JI, Tischfield J, Dick DM, Salvatore JE · PubMed 38108996
Contemporary genome-wide association study (GWAS) methods typically do not account for variability in genetic effects throughout development. We applied genomic structural equation modeling to combine developmentally-informative phenotype data and GWAS to create polygenic scores (PGS) for alcohol use frequency that are specific to developmental stage. Longitudinal cohort studies targeted for gene-identification analyses include the Collaborative Study on the Genetics of Alcoholism (adolescence n = 1,118, early adulthood n = 2,762, adulthood n = 5,255), the National Longitudinal Study of Adolescent to Adult Health (adolescence n = 3,089, early adulthood n = 3,993, adulthood n = 5,149), and the Avon Longitudinal Study of Parents and Children (ALSPAC; adolescence n =
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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Limiting alcohol consumption frequency Moderate
Variant shows robust GWAS association with alcohol use frequency; affects brain and metabolic gene expression
Be mindful of drinking patterns; consider setting personal limits if carrying risk allele