rs11544331 - GPER1, CHLSN

Magnitude 2.0 · 1 study on file

Reported associations

• An exome-wide rare variant analysis of Korean men identifies three novel genes predisposing to prostate cancer - Scientific reports (2020) · Oh JJ, Shivakumar M, Miller J, Verma S, Lee H, Hong SK, Lee SE, Lee Y, Lee SJ, Sung J, Kim D, Byun SS · PubMed 31748686

  ABSTRACT: Since prostate cancer is highly heritable, common variants associated with prostate cancer have been studied in various populations, including those in Korea. However, rare and low-frequency variants have a significant influence on the heritability of the disease. The contributions of rare variants to prostate cancer susceptibility have not yet been systematically evaluated in a Korean population. In this work, we present a large-scale exome-wide rare variant analysis of 7,258 individuals (985 cases with prostate cancer and 6,273 controls). In total, 19 rare variant loci spanning 7 genes contributed to an association with prostate cancer susceptibility. In addition to replicating previously known susceptibility genes (e.g., CDYL2, MST1R, GPER1, and PARD3B), 3 novel genes were ide

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