rs1154433 - ADH1B - ADH1C
Magnitude 2.2 · 2 studies on file
Reported associations
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Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits - Unknown journal (n.d.) · Unknown authors · PubMed 32451486
ABSTRACT: Problematic alcohol use (PAU) is a leading cause of death and disability worldwide. Although genome-wide association studies (GWASs) have identified PAU risk genes, the genetic architecture of this trait is not fully understood. We conducted a proxy-phenotype meta-analysis of PAU combining alcohol use disorder and problematic drinking in 435,563 European-ancestry individuals. We identified 29 independent risk variants, 19 of them novel. PAU was genetically correlated with 138 phenotypes, including substance use and psychiatric traits. Phenome-wide polygenic risk score analysis in an independent biobank sample (BioVU, n=67,589) confirmed the genetic correlations between PAU and substance use and psychiatric disorders. Genetic heritability of PAU was enriched in brain and in conser
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Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations - Unknown journal (n.d.) · Unknown authors · PubMed 30940813
ABSTRACT: Alcohol consumption level and alcohol use disorder (AUD) diagnosis are moderately heritable traits. We conduct genome-wide association studies of these traits using longitudinal Alcohol Use Disorder Identification Test-Consumption (AUDIT-C) scores and AUD diagnoses in a multi-ancestry Million Veteran Program sample (N = 274,424). We identify 18 genome-wide significant loci: 5 associated with both traits, 8 associated with AUDIT-C only, and 5 associated with AUD diagnosis only. Polygenic Risk Scores (PRS) for both traits are associated with alcohol-related disorders in two independent samples. Although a significant genetic correlation reflects the overlap between the traits, genetic correlations for 188 non-alcohol-related traits differ significantly for the two traits, as do
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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genetic predisposition to alcohol use disorder High
Common genetic variation at ADH locus substantially increases AUD risk across populations.
Lifestyle
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heavy or frequent alcohol consumption High
Variant in ADH1C regulatory region affects alcohol-metabolizing enzyme expression, altering AUD risk.
Adhere to standard moderation guidelines; consider more conservative limits given genetic AUD risk.
Screening
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early signs of problematic alcohol use High
Genetic variants in alcohol metabolism pathways influence AUD susceptibility and disorder progression.
Annual AUDIT or similar assessment for tolerance, dependence, or control loss.