rs115433319 - ZNF536
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide association study meta-analysis of blood pressure traits and hypertension in sub-Saharan African populations: an AWI-Gen study - Unknown journal (n.d.) · Unknown authors · PubMed 38104120
ABSTRACT: Most hypertension-related genome-wide association studies (GWASs) focus on non-African populations, despite hypertension (a major risk factor for cardiovascular disease) being highly prevalent in Africa. The AWI-Gen study GWAS meta-analysis for blood pressure (BP)-related traits (systolic and diastolic BP, pulse pressure, mean-arterial pressure and hypertension) from three sub-Saharan African geographic regions (N = 10,775), identifies two novel genome-wide significant signals (p < 5E-08): systolic BP near P2RY1 (rs77846204; intergenic variant, p = 4.95E-08) and pulse pressure near LINC01256 (rs80141533; intergenic variant, p = 1.76E-08). No genome-wide signals are detected for the AWI-Gen GWAS meta-analysis with previous African-ancestry GWASs (UK Biobank (Africa
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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genetic hypertension risk and screening strategy Moderate
Carriers have increased hypertension risk and may benefit from tailored screening and prevention
Lifestyle
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lifestyle modifications for hypertension prevention Moderate
Standard hypertension prevention strategies are appropriate for anyone with genetic predisposition to hypertension
Regular aerobic exercise, DASH diet, sodium restriction, weight management
Screening
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blood pressure screening Moderate
ZNF536 variant associates with hypertension risk at genome-wide significance in 10k+ samples
Annual blood pressure measurement; more frequently if family history or other cardiovascular risk factors