Expressive

rs1154275 - LINC02042 - CD200R1L-AS1

Magnitude 4.5 · 1 study on file

Reported associations

  • Genome-wide association study in takotsubo syndrome - Preliminary results and future directions. - International journal of cardiology (2017) · Eitel I, Moeller C, Munz M, Stiermaier T, Meitinger T, Thiele H, Erdmann J · PubMed 28108127

    Takotsubo syndrome (TS) is an acute non-ischemic cardiomyopathy characterized by transient regional systolic dysfunction of the left and/or right ventricle with still unknown etiology. The aim of the current study was to conduct for the first time a genome-wide association study (GWAS) in a cohort of TS patients to identify potential genetic risk variants. This single-center study was conducted at the University Heart Center Lübeck from 2008 to 2016. DNA isolation was done according to standard protocols. Imputation of genotypes were performed at the Michigan Imputation Server (https://imputationserver.sph.umich.edu) using the 1000G Phase 3 v5 reference panel. The study population consisted of 96 TS patients (91 females, 5 males) with a mean age of 71.9±10.4years and 475 healthy controls

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Takotsubo syndrome risk and cardiac monitoring strategy Moderate

    This genetic variant is significantly associated with Takotsubo cardiomyopathy; cardiologist guidance can inform screening and management decisions.

Lifestyle

  • Regular stress management practice Moderate

    Takotsubo syndrome is predominantly triggered by emotional or physical stress; consistent stress reduction may lower incidence risk.

    Practice meditation, yoga, or deep breathing daily for 30+ minutes

Screening

  • Baseline cardiac assessment with EKG and echocardiography Moderate

    Establishing baseline cardiac parameters in asymptomatic carriers may enable early detection of stress-induced changes.

    Discuss timing and frequency with cardiologist