Expressive

rs115406035 - HLA-DRA - HLA-DRB9

Magnitude 4.5 · 1 study on file

Reported associations

  • Genomic Insights Into Inflammatory Bowel Disease in United States Hispanic Participants: An Ancestry-Focused Study. - Gastroenterology (2026) · Beecham AH, McGovern DPB, Brugger SW, Davis MF, Torres EA, Gomez L, Li D, Lopez-Marte P, Daly MJ, Stevens C, Yang S, Sinha S, Mengesha E, Leavitt J, Damas OM, Quintero MA, Targan SR, Rabizadeh S, Sabic K, Cho JH, Abreu MT, McCauley JL, Haritunians T · PubMed 41661118

    Genetic admixture of United States Hispanic individuals provides a unique opportunity to examine ancestral origins of inflammatory bowel disease (IBD) risk. In ∼7.3K Hispanic participants (1660 IBD cases; 5614 controls), we examined ancestral heterogeneity of IBD clinical phenotypes and sought to identify IBD risk loci that displayed heterogeneity of effect or were ancestry-specific. Association of genetic ancestry with clinical phenotypes was evaluated. We conducted an ancestry-informed genome-wide (GW) association study for IBD, ulcerative colitis, and Crohn's disease (CD) to obtain ancestry-specific effect size estimates for alleles from African (AFR), European (EUR), and Amerindian (AIAN) origin. Ancestry-specific replication was assessed in All of Us Hispanic participants and transf

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • genetic risk for inflammatory bowel disease Moderate

    HLA-DRA/HLA-DRB9 variants affect HLA-mediated immune recognition in the gut, altering susceptibility to inflammatory bowel disease

    Discuss this genetic finding with your physician; early screening may be appropriate given the genetic risk

Screening

  • inflammatory bowel disease symptoms and screening Moderate

    This variant is strongly associated with increased inflammatory bowel disease and ulcerative colitis risk through HLA-mediated immune mechanisms

    Monitor for symptoms like abdominal pain, diarrhea, or rectal bleeding; discuss screening with your healthcare provider