Expressive

rs11540050 - YKT6

Magnitude 2.2 · 2 studies on file

Reported associations

  • A scalable variational inference approach for increased mixed-model association power - Unknown journal (n.d.) · Unknown authors · PubMed 39789286

    ABSTRACT: The rapid growth of modern biobanks is creating new opportunities for large-scale genome-wide association studies (GWASs) and the analysis of complex traits. However, performing GWASs on millions of samples often leads to trade-offs between computational efficiency and statistical power, reducing the benefits of large-scale data collection efforts. We developed Quickdraws, a method that increases association power in quantitative and binary traits without sacrificing computational efficiency, leveraging a spike-and-slab prior on variant effects, stochastic variational inference and graphics processing unit acceleration. We applied Quickdraws to 79 quantitative and 50 binary traits in 405,088 UK Biobank samples, identifying 4.97% and 3.25% more associations than REGENIE and 22.71%

  • Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes - Unknown journal (n.d.) · Unknown authors · PubMed 33972514

    ABSTRACT: Serum concentration of hepatic enzymes are linked to liver dysfunction, metabolic and cardiovascular diseases. We perform genetic analysis on serum levels of alanine transaminase (ALT), alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) using data on 437,438 UK Biobank participants. Replication in 315,572 individuals from European descent from the Million Veteran Program, Rotterdam Study and Lifeline study confirms 517 liver enzyme SNPs. Genetic risk score analysis using the identified SNPs is strongly associated with serum activity of liver enzymes in two independent European descent studies (The Airwave Health Monitoring study and the Northern Finland Birth Cohort 1966). Gene-set enrichment analysis using the identified SNPs highlights involvement in liver developm

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Omega-3 fatty acids Moderate

    Omega-3 fatty acids reduce triglycerides, particularly important given genetic predisposition to elevation

    2-3 servings fatty fish weekly or omega-3 supplement with 1-2g combined EPA plus DHA daily

  • Refined carbohydrates and added sugars Moderate

    Refined carbs raise triglycerides; rs11540050-T carriers show genetic predisposition to elevated triglycerides

    Limit refined grains, added sugars, and excess alcohol

Screening

  • Alkaline phosphatase and liver enzymes Moderate

    rs11540050-G allele is associated with elevated alkaline phosphatase in large population studies

    Include liver function panel in routine screening

  • Triglyceride levels Moderate

    rs11540050-T allele is associated with elevated triglyceride levels in a large population cohort

    Annual fasting triglyceride measurement