Expressive

rs11540049 - ANTKMT

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways. - Nature genetics (2022) · Watanabe K, Jansen PR, Savage JE, Nandakumar P, Wang X, Hinds DA, Gelernter J, Levey DF, Polimanti R, Stein MB, Van Someren EJW, Smit AB, Posthuma D · PubMed 35835914

    Insomnia is a heritable, highly prevalent sleep disorder for which no sufficient treatment currently exists. Previous genome-wide association studies with up to 1.3 million subjects identified over 200 associated loci. This extreme polygenicity suggested that many more loci remain to be discovered. The current study almost doubled the sample size to 593,724 cases and 1,771,286 controls, thereby increasing statistical power, and identified 554 risk loci (including 364 novel loci). To capitalize on this large number of loci, we propose a novel strategy to prioritize genes using external biological resources and functional interactions between genes across risk loci. Of all 3,898 genes naively implicated from the risk loci, we prioritize 289 and find brain-tissue expression spec

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Genetic insomnia predisposition and sleep management High

    Multiple large GWAS cohorts replicate significant association between rs11540049 T allele and insomnia risk.

Lifestyle

  • Sleep hygiene optimization High

    Consistent sleep schedule and environmental optimization may reduce severity of genetically-influenced insomnia risk.

    Maintain consistent bedtime and wake time; optimize sleep environment for darkness, cool temperature, and quiet

Screening

  • Sleep quality and insomnia symptoms High

    rs11540049 T allele associates with significantly increased insomnia risk through effects on CCDC78 expression in brain regions.

    Assess sleep quality regularly; seek clinical evaluation if insomnia symptoms develop