rs1153996 - RNU6-334P - RAB9BP1

Magnitude 2.2 · 1 study on file

Reported associations

• 6q12 and 11p14 variants are associated with postnatal exhaled nitric oxide levels and respiratory symptoms. - The Journal of allergy and clinical immunology (2017) · Fuchs O, Gorlanova O, Latzin P, Schmidt A, Schieck M, Toncheva AA, Michel S, Gaertner VD, Kabesch M, Frey U · PubMed 28109725

  Exhaled nitric oxide (eNO) is a biomarker of airway inflammation and seems to precede respiratory symptoms, such as asthma, in childhood. Identifying genetic determinants of postnatal eNO levels might aid in unraveling the role of eNO in epithelial function or airway inflammation and disease. We sought to identify genetic determinants of early postnatal eNO levels and subsequent respiratory symptoms during the first year of life. Within a population-based birth cohort, eNO levels were measured in healthy term infants aged 5 weeks during quiet tidal breathing in unsedated sleep. We assessed associations of single nucleotide polymorphisms with eNO levels in a genome-wide association study and subsequent symptoms of lower respiratory tract infections during the first year of life and asked w

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